MTHFR Toolkits and Checklists

Our Educators’ Guide to Methylene tetrahydrofolate reductase (MTHFR) is designed to spring-board that discussion between you, the school nurse and classroom teacher(s).  In our Educators’ Guide we give you an easy explanation of MTHFR, the difference between severe MTHFR and the common form, how high levels may impact your child, how teachers and nurses can help, possible medicine side effects, helpful tips for success, and educational accommodations and additional services that might benefit your student. We know that teachers don’t have a lot of time, so this two page guide is the perfect amount of content to help get the conversation started.


When you have HCU or any other special dietary needs, being ready to handle difficult situations requires special planning, in addition to the typical things everyone needs to consider in the event of an emergency or natural disaster. Here are some key things to think about and discuss with your family today.


Prepare yourself in advance!

Special Education services are available for eligible students with disabilities. This handbook provides information about procedures, answers to frequently asked questions, and links to other resources. This information is meant to be an introduction to special education and may vary between states. For specific laws and regulations to special education in your state, visit your State Department of Education.

Outside Resources

Homocystinuria caused by 5,10-methylenetetrahydrofolate reductase (MTHFR) deficiency occurs when the body makes too little MTHFR enzyme or none at all, or it makes MTHFR enzyme that does not work properly. Enzymes are proteins that regulate the body’s tissues and organs. Specifically, MTHFR helps convert an important amino acid—homocysteine— back to methionine, another important amino acid.

When this process does not occur as it should, blood levels of homocysteine increase and blood levels of methionine decrease. This causes harmful symptoms to develop.

E-HOD consortium developed information booklets on homocystinurias and related diseases for children of school age and for adults/carers. Booklets in different languages are available for free download and non-comercial distribution under flags shown below.

Would you like to request a physical copy of any of the tools seen above?

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